ABSTRACT
The near-infrared-IIb (NIR-IIb, 1 500-1 700 nm) window fluorescence with long emission wavelength has reduced light scattering and tissue auto-fluorescent background, achieving deep tissue imaging with high spatial resolution. Herein, we prepared an NIR-IIb fluorescent quantum dots (QDs) composed of lead sulfide (PbS). The fluorescence spectrum of PbS QDs were adjusted by controlling the size of the PbS core. Cadmium sulfide (CdS) shell was synthesized by the cation exchange method to form the core/shelled lead sulfide/cadmium sulfide quantum dots (CSQDs). The surface of CSQDs was modified with polyethylene glycol (PEG) to increase their stability in aqueous solution. The resulting PEG-modified CSQDs (PEG-CSQDs) had the emission peak at ~1 550 nm with quantum yield of 7.2%. The animal procedures were approved by the Institutional Animal Care and Use Committee (IACUC) of Fudan University School of Pharmacy. At 2 h postinjection, PEG-CSQDs clearly delineated the tumor region of mice bearing orthotopic CT26-Luc colon cancer model in the NIR-IIb fluorescence imaging. The fluorescent intensity ratio of primary tumor and adjacent normal tissue was 42.3, and that of metastatic tumor and adjacent normal tissue was 22.3, which allowed to detect the primary tumor of 3.4 mm×2.5 mm in dimension and the metastatic tumor of 1.2 mm×0.9 mm in dimension, and accurately guided the excision of tumors. The PEG-CSQDs prepared in this study provided a new approach for the early diagnosis and guidance of surgical resection of colon cancer.
ABSTRACT
Objective To investigate the effect of Rivastaban tablet combined with psychological intervention after radiofrequency ablation of paroxysmal atrial fibrillation. Methods According to the random number table method, 86 patients of paroxysmal atrial fibrillation ablation were divided into the control group and the observation group. The control group was treated with Rivastaban table and routine nursing. The observation group was given psychological intervention on the basis treatment of the control group. The quality of life of two groups was evaluated by SF-36 quality of life scale, anxiety and depression symptoms of two groups were evaluated before and after the intervention. Recurrence of two groups were observed by followed-up of 6 to 12 months. Results The anxiety and depression scores of the observation group were significantly lower than those of the control group. The anxiety and depression scores of the two groups were significantly lower than those before treatment (P<0.05). The body function, physical character, social function, body pain, body emotion, vitality, mental health and overall health score of the observation group were significantly higher than those of the control group (P<0.05). The recurrence rate was 4.65% (2/43) in the observation group, which was significantly lower than (18.60%, 8/43) in the control group (χ2=4.07, P=0.04). Conclusion Radiotherapy with radiofrequency ablation of paroxysmal atrial fibrillation combined with Rivastaban tablet plus psychological intervention could help improve the mental state of patients, reduce their recurrence and improve their quality of life.
ABSTRACT
Objective To investigate the effect of Rivastaban tablet combined with psychological intervention after radiofrequency ablation of paroxysmal atrial fibrillation. Methods According to the random number table method, 86 patients of paroxysmal atrial fibrillation ablation were divided into the control group and the observation group. The control group was treated with Rivastaban table and routine nursing. The observation group was given psychological intervention on the basis treatment of the control group. The quality of life of two groups was evaluated by SF-36 quality of life scale, anxiety and depression symptoms of two groups were evaluated before and after the intervention. Recurrence of two groups were observed by followed-up of 6 to 12 months. Results The anxiety and depression scores of the observation group were significantly lower than those of the control group. The anxiety and depression scores of the two groups were significantly lower than those before treatment (P<0.05). The body function, physical character, social function, body pain, body emotion, vitality, mental health and overall health score of the observation group were significantly higher than those of the control group (P<0.05). The recurrence rate was 4.65% (2/43) in the observation group, which was significantly lower than (18.60%, 8/43) in the control group (χ2=4.07, P=0.04). Conclusion Radiotherapy with radiofrequency ablation of paroxysmal atrial fibrillation combined with Rivastaban tablet plus psychological intervention could help improve the mental state of patients, reduce their recurrence and improve their quality of life.